Generally has larger file sizes compared to the 32-bit version Generally compatible with a wide range of add-ins and third-party software Some add-ins may only be compatible with the 64-bit version, verify compatibility before installation Differences between Microsoft Office 64 bit and Microsoft Office 32 bitĬompatible with 64-bit Windows operating systemsĬompatible with 32-bit and 64-bit Windows operating systemsĬan handle larger amounts of memory, beneficial for memory-intensive tasks.